Combined polyphenols in Psidium guajava-citrus limon leaf extract attenuate fructose-induced cardiac injury by modulating metabolic and oxidative stress pathways in rats.

ABSTRACT:

Background

High fructose consumption is associated with metabolic and cardiovascular dysfunction. Polyphenol-rich lemon and guava leaves may protect the heart.

Objective

This study investigated the protective effects of Citrus limon leaf extracts, individually and in combination with Psidium guajava, against high fructose-induced cardiac injury in rats. We hypothesized that the polyphenol-rich extracts would attenuate cardiac damage through metabolic and oxidative stress modulation, with synergistic enhancement in the combined treatment.

Methods

The chemical composition of lemon and guava leaves was analyzed using LC-ESI-MS/MS, along with total phenolic, flavonoid, and antioxidant assays. Male Sprague-Dawley rats (n = 6/group) were divided into: a control group, a fru

SUBMITTER: Essa HA 

PROVIDER: S-EPMC12822947 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature