Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer is a highly aggressive tumor with a poor prognosis due to challenging early diagnosis and limited treatment options. CHEK1, a crucial cell cycle regulator, is important in tumor development, but its role in pancreatic cancer remains under-researched in terms of expression, function, and regulation.

Objective

To study the effect of CHEK1 on proliferation, migration and cell cycle of pancreatic cancer, and to construct a prognostic prediction model to investigate the effect of CHEK1 on the prognosis of pancreatic cancer.

Methods

We conducted a systematic investigation into the expression characteristics and biological functions of CHEK1 in pancreatic cancer, utilizing an integration of bioinformatics analyses and in vitro experiments. Initia

SUBMITTER: Wei X 

PROVIDER: S-EPMC12822972 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature