Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) intravenous self-administration in female and male rats.

ABSTRACT:

Rationale

Stimulant drug users vary in their substance of choice and may, in some cases, switch up their preferred substance based on availability, cost or other factors. Poly-substance use is rarely assessed in rodent models of drug seeking.

Objectives

To determine if training drug alters the apparent reinforcing properties of methamphetamine (MA) and α-pyrrolidinopentiophenone (α-PVP).

Methods

Female and male Wistar rats (N = 8 per group) were trained in the intravenous self-administration (IVSA) of α-PVP or MA. The impact of dose substitution (0.0125, 0.0250, 0.100, 0.300 mg/kg/infusion) for each training drug was then assessed in all groups under FR and Progressive Ratio schedules of reinforcement.

Results

Male and female rats obtained similar numbers of in

SUBMITTER: Gutierrez A 

PROVIDER: S-EPMC12823102 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature