Photocatalytic C-F bond activation in small molecules and polyfluoroalkyl substances.

ABSTRACT: Organic halides are highly useful compounds in chemical synthesis, in which the halide serves as a versatile functional group for elimination, substitution and cross-coupling reactions with transition metals or photocatalysis^1-3. However, the activation of carbon-fluorine (C-F) bonds-the most commercially abundant organohalide and found in polyfluoroalkyl substances (PFAS), or 'forever chemicals'-is much rarer. Current approaches based on photoredox chemistry for the activation of small-molecule C-F bonds are limited by the substrates and transition metal catalysts needed⁴. A general method for the direct activation of organofluorines would have considerable value in organic and environmental chemistry. Here we report an organic photoredox catalyst system that can eff

SUBMITTER: Liu X 

PROVIDER: S-EPMC12823158 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature