Serum albumin and hypertension: The mediating roles of BMI, C-reactive protein and extracellular fluid.

ABSTRACT: The relationship between serum albumin and hypertension has attracted much attention. We sought to further validate these findings and explore the underlying mediators.

Methods and study design

This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999-2004), including 19,507 participants. Multivariable weighted logistic were employed to investigate the association of serum albumin with hypertension. The potential mediating role of body mass index (BMI), C-reactive protein (CRP), and extracellular fluid (ECF) was explored. Secondary analyses included subgroup analyses and restricted cubic spline (RCS).

Results

Serum albumin per 1 g/L increase was associated with 10% lower hypertension prevalence (OR=0.90, 95%CI:0.89-0.91, p

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12823252 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature