Immunohistochemical Analysis of Tom20 in Choroid Plexus Epithelial Cells From Elderly Brains With Neurodegenerative Diseases.

ABSTRACT: The choroid plexus (CP) contributes to cerebrospinal fluid (CSF) production and regulation of circadian rhythm. Recently, many neuroimaging studies have reported enlarged CP volumes in patients with neurodegenerative diseases, including Alzheimer's disease (AD). While previous morphometric analysis revealed age-related enlargement of CP epithelial cells, the metabolic significance of such morphological changes including eosinophilic enlarged changes remains unclear. In this study, we investigated mitochondrial alterations in CP epithelial cells using immunohistochemistry for Tom20, a marker of the mitochondrial outer membrane. Temporal lobes, including CP, in patients with AD, vascular dementia, Parkinson's disease, and multiple system atrophy, and neuropathologically unremarkable controls

SUBMITTER: Murakami R 

PROVIDER: S-EPMC12823287 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature