Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.

ABSTRACT:

Article highlights

There is a paucity of data regarding defects in insulin signaling in insulin-resistant human white adipose tissue (WAT). The tether containing a UBX domain for GLUT4 (TUG) protein, which retains GLUT4 vesicles, was increased in WAT of participants with greater insulin resistance in three different cohorts with obesity. Components of the TUG regulatory signaling pathway were differentially expressed between participants with greater insulin resistance and those with greater insulin sensitivity. TUG may provide an important pharmacologic target in the treatment or prevention of metabolic dysfunction in patients with obesity.

SUBMITTER: Strober JW 

PROVIDER: S-EPMC12823340 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature