Examining the needs, outcomes and current treatment pathways of 2461 people with treatment-resistant depression: mixed-methods study.

ABSTRACT:

Background

A substantial subset of patients with major depressive disorder (MDD) experience treatment-resistant depression (TRD), typically defined as failure to respond to at least two sequential antidepressant trials at adequate dose and length.

Aims

To examine clinical and service-level associations of TRD, and the experiences of people with TRD and clinicians involved in their care within a large, diverse National Health Service trust in the UK.

Method

This mixed-methods study integrated quantitative analysis of electronic health records with thematic analysis of semi-structured interviews. Chi-squared tests and one-way analysis of variance were used to assess associations between lines of antidepressant treatments and sociodemographic and clinical variables, and

SUBMITTER: Gill K 

PROVIDER: S-EPMC12823348 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature