The Effect of Creatine Monohydrate on Mental Disorders: A Systematic Review of Randomized Controlled Trials: Effet du monohydrate de creatine sur les troubles mentaux : examen systematique des essais controles a repartition aleatoire.

ABSTRACT: ObjectiveThe objective of this systematic review is to synthesize and evaluate the evidence involving creatine monohydrate supplementation (CrM) across mental disorders.MethodsMEDLINE, Embase, Cochrane, and PsycINFO were searched up to 09/30/2025 for randomized controlled trials (RCTs) investigating the effect of CrM on psychiatric symptoms and safety in participants with a mental disorder. Risk of bias was assessed.ResultsSix articles from five RCTs were included (CrM: n = 126, placebo: n = 112; mean age=36 ± 14 years; male sex = 26%). Four RCTs reported on major depressive disorder (MDD), one bipolar depression. No other mental disorders were investigated. Two RCTs were low risk of bias and three had some concerns. CrM dosing ranged from 2 to 10 g/day for 4-8 weeks as adjunct treatment.

SUBMITTER: Jeryous Fares B 

PROVIDER: S-EPMC12823350 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature