Impact of cumulative blood pressure load during early pregnancy on the risk of low birth weight: the BOSHI study.

ABSTRACT: This study investigated the association between cumulative blood pressure (BP) load, defined as the area above a threshold reflecting the duration and magnitude of BP elevation, and low birth weight (LBW). We included 729 pregnant women in this prospective cohort study. Home BP measurements collected at 10 weeks 0 days and 15 weeks 6 days were assessed. The participants were classified into three groups based on their cumulative BP load: (1) no cumulative BP load elevation, (2) isolated cumulative BP load elevation (with normal average BP), and (3) high average BP (average BP above the normal range). Normal ranges (systolic BP < 115 mmHg, diastolic BP < 75 mmHg) were defined following the guidelines; BP load threshold (systolic BP < 104 mmHg, diastolic BP < 62 mmHg) was set using median av

SUBMITTER: Nobayashi H 

PROVIDER: S-EPMC12823421 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature