Visit-to-visit blood pressure variability and dementia risk after considering antihypertensive treatment: real-world data from the Japanese National Health Insurance.

ABSTRACT: This retrospective cohort study evaluated the association between visit-to-visit blood pressure (BP) variability and dementia risk, considering antihypertensive drug classes and medication adherence using Japanese National Health Insurance data (2015-2023) of 301,448 participants (age: 66.6 years, male: 38.6%). Visit-to-visit systolic BP (SBP) variability was assessed using the coefficient of variation (CV) from five annual health check-ups. The outcome was antidementia drug initiation as a proxy for dementia diagnosis and was analyzed using Fine-Gray models, with death as the competing outcome. For participants untreated/treated with antihypertensive medication, 366/298 initiated antidementia drugs during 2.20 ± 1.19/2.11 ± 1.19 years of follow-up, respectively. The highest SBP-CV sextile

SUBMITTER: Satoh M 

PROVIDER: S-EPMC12823422 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature