Architecture of the neutrophil compartment.

ABSTRACT: Neutrophils exhibit remarkable phenotypic and functional diversity across tissues and diseases^1,2, yet the lack of understanding of how this immune compartment is globally organized challenges translation to the clinic. Here we performed single-cell transcriptional profiling of neutrophils spanning 47 anatomical, physiological and pathological scenarios to generate an integrated map of the global neutrophil compartment in mice, which we refer to as NeuMap. NeuMap integrates and expands existing models^3,4 to generate fundamental new insights; it reveals that neutrophils organize in a finite number of functional hubs that distribute sequentially during maturation to then branch out into interferon-responsive and immunosuppressive states, as well as a functionally silent

SUBMITTER: Cerezo-Wallis D 

PROVIDER: S-EPMC12823425 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature