Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a large genetic component¹. It affects around 5% of children and 2.5% of adults², and is associated with several severe outcomes^3-11. Common genetic variants associated with the disorder have been identified^12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 × 10^-6; odds ratios 5.55-15.13) that are implicated in ADHD. The protein-protein interaction networks of these three genes were enriched for rare-variant risk genes of other neurodevelop

SUBMITTER: Demontis D 

PROVIDER: S-EPMC12823435 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature