The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension.

ABSTRACT: New biomarkers are needed to detect and follow individuals with World Health Organization group 1.1 pulmonary hypertension (idiopathic pulmonary arterial hypertension (IPAH)). As NOTCH3 cleavage occurs constitutively in the lungs of individuals with IPAH, we investigated whether the NOTCH3 extracellular domain (NOTCH3-ECD) shed into serum could be used as a robust biomarker for IPAH. In three geographically distinct cohorts comprising 341 individuals with IPAH (267 women, 74 men) and 376 healthy individuals (278 women, 98 men), serum NOTCH3-ECD levels were significantly higher in individuals with IPAH (mean ± s.d.: 19.9 ± 5.5 ng ml^-1) compared to controls (10.5 ± 1.9 ng ml^-1; P < 0.001), with consistent results among the three cohorts. NOTCH3-ECD levels correlated wit

SUBMITTER: Hernandez M 

PROVIDER: S-EPMC12823441 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature