Blood Cell Mitochondrial Respiration Increases With Age and Varies by Sex in Healthy Adults.

ABSTRACT: Mitochondrial dysfunction is recognized as a biological hallmark of aging; however, bioenergetic capacity across the healthy human life course remains insufficiently characterized. While aging is generally associated with a systemic decline in mitochondrial function ("age-related bioenergetic decline"), recent research suggests that age-related bioenergetic differences are context dependent. Blood cells are extensively utilized as accessible samples for human bioenergetic profiling; therefore, our goal was to characterize bioenergetic capacity in platelets, peripheral blood mononuclear cells (PBMCs), monocytes, and lymphocytes of healthy adults from the San Diego Nathan Shock Center Clinical Cohort representative of the adult life course (20-80+ years of age). In our sample of 72 adults, w

SUBMITTER: Phang HJ 

PROVIDER: S-EPMC12823460 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature