Octopamine modulates the innate immune response in <i>Drosophila melanogaster</i>.

ABSTRACT:

Background

Octopamine, the functional equivalent of noradrenaline in invertebrates, is a key neuromodulator that also influences immune functions. However, the receptor‑specific roles of octopamine in regulating innate immunity in Drosophila melanogaster remain incompletely understood.

Methods

Using loss‑of‑function mutants for the two major octopamine receptors Octβ1R and Octβ2R, combined with systemic bacterial infection models, bacterial clearance assays, in vivo and in vitro phagocytosis assays, and quantification of antimicrobial peptide (AMP) gene expression, we dissected the contribution of each receptor to distinct immune effector modules.

Results

Flies deficient in Octβ1R or Octβ2R exhibited reduced survival and impaired bacterial clearance following s

SUBMITTER: Uliczka K 

PROVIDER: S-EPMC12823492 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature