Differential roles for CLA-1L and UNC-10 in endosomal maturation and peptide release at <i>C. elegans</i> synapses impacting lifespan.

ABSTRACT: Caenorhabditis elegans encode two synaptic proteins linked to the Rim/Piccolo/Fife-family, through conserved motifs: 1) Clarinet (CLA-1), has 3 isoforms (short(S), medium(M) and long(L)) that are anchored at the active zone through a common C-terminal domain and 2) UNC-10/Rim that is also highly enriched at the presynaptic density. Both the cla-1 and unc-10 mutants have demonstrable effects on synaptic transmission and in combination produce a synergistic impact that virtually eliminates synaptic transmission and that has yet to be fully understood. Recently, CLA-1L and UNC-10 were shown to differentially regulate key active zone components, culminating in reduced Ca²⁺ channels and UNC-13 levels, but these changes cannot account for the severity of th

SUBMITTER: Krout M 

PROVIDER: S-EPMC12823496 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature