Assessing the endothelium's role in COVID-19 severity using the HUVEC model.

ABSTRACT:

Introduction

Coronavirus disease 2019 (COVID-19) has been widely associated with intense systemic inflammation, endothelial injury, and a high incidence of thrombotic complications, which together contribute to disease severity and poor clinical outcomes. While endothelial dysfunction, dysregulated cytokine production, and oxidative stress are recognized features of severe COVID-19, the direct impact of circulating factors from infected individuals on endothelial cell behavior remains insufficiently characterized. Here, we examined how serum from patients with severe COVID-19 and from convalescent individuals modulates endothelial activation, inflammatory responses, and oxidative stress using human umbilical vein endothelial cells as an in vitro model.

Methods

Venous blood s

SUBMITTER: Santana SS 

PROVIDER: S-EPMC12823526 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature