Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.

ABSTRACT:

Background

The tuberoinfundibular peptide of 39 residues (TIP39) is a small peptide first extracted in 1997, which has garnered limited research attention. It belongs to the parathyroid hormone (PTH)-related peptides family and specifically binds the parathyroid receptor type 2 (PTH2R). It is gaining attention for its roles in mood regulation, maternal behavior, and social functions. Its potential in modulating these processes possibly positions TIP39 as an underexplored candidate for exploring complex physiological functions of postpartum depression.

Aims

Given the accumulating evidence of TIP39's involvement in various regulatory functions, this review aims to investigate its potential as a common pathway for postpartum depression PPD-related symptoms, including depressive

SUBMITTER: Wang S 

PROVIDER: S-EPMC12823539 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature