Small molecule inhibitor targets OmpV to treat pandemic Vibrio cholerae infection.

ABSTRACT: Cholera, a severe diarrhoeal illness caused by Vibrio cholerae (V. cholerae), poses a significant threat to public health worldwide. The emergence of multidrug-resistant V. cholerae strains underscores the urgent need for preventive and therapeutic interventions. In this study, we elucidate the role of outer membrane protein V (OmpV) in the virulence of V. cholerae and propose a therapeutic strategy targeting OmpV. Subcellular localization analysis shows that OmpV is present in both the bacterial outer membrane (OM) and bacterial extracellular vesicles (BEVs). When V. cholerae enters the small intestine, OmpV is activated by the CarSR two-component system in response to cationic antimicrobial peptides (CAMPs) in the small intestine, leading to increased bacterial pathogenicity. The upregul

SUBMITTER: Liu R 

PROVIDER: S-EPMC12823570 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature