Circulating microRNAs miR-21-5p, miR-23a-3p and miR-26a-5p reflect clinical and molecular features of aging.

ABSTRACT: Circulating microRNAs (miRNAs) are emerging as key regulators of aging and age-related diseases. Among them, the so-called inflammamiRs miR-21-5p, miR-23a-3p, and miR-26a-5p have been repeatedly linked to inflammation, tissue remodelling, and metabolic dysregulation. In this cross-sectional study, we investigated their expression in older adults (65-103 years) to explore associations with frailty, comorbidity, and major clinical and functional indicators of aging. Plasma miRNA levels were measured by quantitative PCR and correlated with comprehensive clinical, functional (frailty status, Activities of Daily Living [ADL], and Cumulative Illness Rating Scale [CIRS]), and biochemical parameters. Bioinformatic pathway analyses were also performed to identify shared molecular targets. All three

SUBMITTER: La Grotta R 

PROVIDER: S-EPMC12823579 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature