Contributions of selenoproteins to breast cancer etiology and racial disparity.

ABSTRACT:

Purpose

Breast cancer etiology is multifactorial with African American women experiencing a significant health disparity in clinical presentation and outcomes. The selenium-containing protein SELENOF has been implicated in breast carcinogenesis by cell culture and animal studies. SELENOF translation is highly regulated in part by the RNA helicase eIF4a3, which binds to the key regulatory regions in the SELENOF mRNA and suppress its translation. In addition, SELENOP, the primary selenium transporter, plays a critical role in selenium delivery to tissues and may influence selenoprotein synthesis. This study aimed to examine the levels of SELENOF and eIF4a3, along with SELENOF and SELENOP genotypes, in breast cancer tissues from African American and Caucasian women METHODS: To study t

SUBMITTER: Bera S 

PROVIDER: S-EPMC12823618 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature