Relationship between bone mineral density and strength derived from 3D-shaper and HR-pQCT in patients with X-linked osteoporosis related to PLS3.

ABSTRACT: In individuals with PLS3 genetic variants, HR-pQCT and 3D-DXA analysis indicate a larger trabecular than cortical deficit. This is consistent with the lower aBMD from DXA at the lumbar spine than at the total hip.

Introduction

X-linked osteoporosis due to PLS3 genetic variants is a rare disease, clinically affecting men more than women. This study aimed to explore relationships between parameters obtained from DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT), and 3D-DXA in thirteen adults with PLS3 variants.

Methods

The parameters were for 3D-DXA: trabecular volumetric bone mineral density (Tb.BMD), cortical surface BMD (Ct.sBMD), and bone strength at the total hip using 3D-DXA-based finite element models (3D Shaper® software, v2.14.0), and for HR-pQ

SUBMITTER: Zervou Z 

PROVIDER: S-EPMC12823622 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature