Three years later: tracking bothersome symptoms and impacts for people with early Parkinson's disease.

ABSTRACT:

Background

Understanding how meaningful symptoms and impacts of Parkinson's change with time is necessary to select endpoints for clinical trials and to support clinical practice.

Objective

This study aimed to longitudinally evaluate the prevalence, bothersomeness, and functional impacts of early Parkinson's symptoms on daily life over a three-year study duration.

Methods

32 participants with early Parkinson's completed qualitative interviews to map symptoms and impacts of disease annually for three years. Symptom maps were content coded for frequency and bothersomeness of symptoms and presence of related impacts. Non-parametric generalized linear mixed models (GLMM) were used to evaluate change over time.

Results

The most bothersome motor symptoms were tremor,

SUBMITTER: Mammen JR 

PROVIDER: S-EPMC12823644 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature