Methylone promotes neurite outgrowth and has long-lasting effects on fear extinction learning.

ABSTRACT: Post-traumatic stress disorder (PTSD) is a prevalent and debilitating disorder, and available treatments are limited. TSND-201 (methylone) is in clinical trials for PTSD, showing potential to have rapid, robust and long-lasting benefit without direct agonist/antagonist activity at 5HT2A. Alterations in structural neuroplasticity are a well-studied mechanism that may underlie both the pathophysiology and treatment of PTSD. Previous work showed that methylone rapidly induced neuroplasticity-related factors in PTSD-relevant brain areas. The current study was undertaken to determine whether methylone affected structural neuroplasticity (e.g., neurite outgrowth) and whether its effects may also be long-lasting. Methylone stimulated neurite outgrowth, specifically increasing the number of branch

SUBMITTER: Warner-Schmidt J 

PROVIDER: S-EPMC12823647 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature