Personalized intensity modulation radiation therapy auto-planning for esophageal cancer.

ABSTRACT: Esophageal cancer (EC) is among the most common malignancies worldwide, with radiotherapy as a key treatment. Intensity-modulated radiation therapy (IMRT) offers highly conformal dose distributions while sparing critical organs; however, planning is complex due to the esophagus' central location and proximity to vital structures. This study aimed to develop a personalized, automated IMRT planning system for EC. A retrospective analysis of 301 patients treated with 45 Gy in 25 fractions was conducted. Patient data, including CT images, structure sets, and clinical plan (CP) dose distributions, were collected to develop and internally validate the model. Geometric predictors of lung and heart doses were identified based on planning target volume (PTV) shape, size, and proximity to organs. Ex

SUBMITTER: Lin CY 

PROVIDER: S-EPMC12823690 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature