Caveolin-1 Regulates Ultrastructural Alterations of Astrocytes in Chronic Cerebral Hypoperfusion.

ABSTRACT: Cerebral white matter exhibits heightened susceptibility to chronic hypoperfusion. Increasing evidence implicates glial cells, notably astrocytes, in mediating chronic ischemic demyelination. To elucidate the involvement of astrocytes in ischemic white matter pathologies, we conducted an ultrastructural characterization of intracellular contents in reactive astrocytes of mice following bilateral carotid artery stenosis (BCAS), a model of chronic cerebral hypoperfusion. BCAS triggered robust activation of astrocytes, with electron-dense dark astrocytes demonstrating cytoplasmic/nuclear hypercondensation via transmission electron microscopy, in the corpus callosum. These astrocytes exhibited markedly elevated cellular stress hallmarks, including mitochondria alteration, Golgi cisternal vesic

SUBMITTER: Wu M 

PROVIDER: S-EPMC12823752 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature