Integrated transcriptome and metabolome analyses reveal key genes regulating jujuboside biosynthesis in <i>Ziziphus jujuba</i> var. <i>spinosa</i>.

ABSTRACT: The seeds of Ziziphus jujuba var. spinosa are a traditional Chinese medicine for treating insomnia, with jujuboside A and jujuboside B as their core bioactive components. However, the biosynthetic pathways and regulatory mechanisms of these triterpenoid saponins remain poorly understood. In this study, we investigated the accumulation patterns of jujube saponins across 10 varieties at 45, 65, and 85 days after flowering (DAF). Integrated transcriptomic and metabolomic analyses revealed 2,040 differentially expressed genes (DEGs) and 1,593 differentially accumulated metabolites (DAMs). Among these, 35 core DEGs were consistently significant across comparisons, enriched in saponin metabolism, monooxygenase activity, and glycosylation processes. A Uridine Diphosphate (UDP)-gluco

SUBMITTER: Geng D 

PROVIDER: S-EPMC12823797 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature