Altered circRNAs: a novel potential mechanism for the functions of extracellular vesicles derived from platelet-rich plasma.

ABSTRACT: Platelet-rich plasma (PRP) has been widely applied in clinical practice for tissue repair and regeneration. Recent studies have reported that large amounts of extracellular vesicles (EVs) derived from PRP (PRP-EVs) are also involved in the functions of tissue repair and regeneration, except for the secreted growth factors. However, the relevant mechanisms of PRP-EVs remain unknown. In this study, we attempted to reveal the potential circular RNA (circRNA) mechanisms of PRP-EVs using high-throughput RNA sequencing (RNA-seq) technique and bioinformatics analysis. Six healthy donors were enrolled in this study, including three donors for the isolation of PRP-EVs and three donors for the isolation of EVs derived from blood plasma (plasma-EVs). As a result, we confirmed that PRP activation by t

SUBMITTER: Niu L 

PROVIDER: S-EPMC12823818 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature