Atrial fibrillation signals associated with overactive bladder drugs across JADER and FAERS: disproportionality and time-to-onset analyses.

ABSTRACT:

Introduction

Overactive bladder (OAB) drugs are widely prescribed, yet the occurrence of atrial fibrillation (AF) after treatment initiation remains poorly characterized.

Methods

We evaluated reports of AF associated with OAB medications using two spontaneous reporting systems (SRSs): the Japanese Adverse Drug Event Report (JADER) database and the U.S. FDA Adverse Event Reporting System (FAERS). We screened eight agents and assessed signals using three disproportionality metrics: the reporting odds ratio (ROR), proportional reporting ratio (PRR), and Bayesian confidence propagation neural network (BCPNN). For drugs showing signals in both databases, we conducted stratified analyses by sex, age, and number of concomitant medications, and evaluated time-to-onset (TTO) using We

SUBMITTER: Nagura K 

PROVIDER: S-EPMC12823915 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature