Insulin resistance and atrial fibrillation: from disease onset to post-ablation outcomes: a systematic review and meta-analysis.

ABSTRACT:

Objective

To systematically evaluate the impact of insulin resistance (IR) on the risk of new-onset atrial fibrillation (AF) and post-ablation recurrence, and to elucidate underlying mechanisms and translational implications for early identification and precision management of high-risk populations.

Methods

A comprehensive meta-analysis was conducted by integrating 30 high-quality cohort studies from multiple countries, incorporating IR markers such as TyG index and HOMA-IR. Random-effects models were used to estimate the association between IR and both AF incidence and ablation recurrence. Subgroup analyses, sensitivity analyses, meta-regression, and GRADE quality assessment were performed to explore heterogeneity and robustness. Mechanistic pathways were systematically sum

SUBMITTER: Huang T 

PROVIDER: S-EPMC12823920 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature