Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes.

ABSTRACT:

Background

Mild cognitive impairment (MCI) is a cognitive decline syndrome in the elderly, often a precursor to dementia. It is a heterogeneous condition that can signal degenerative disorders like Alzheimer's or non-degenerative conditions such as vascular issues, depression, or poorly managed diabetes. Early detection of MCI is crucial for timely intervention, and differentiating its phenotypes helps in understanding its causes, progression, and treatment. EEG, which records brain electrical activity, consists of rhythmic and arrhythmic components. Examining these inherently overlapping EEG components calls for quantification, ensuring that an appropriate physiological mechanism is attributed to a given neural response. This study explores the interaction between APOE ε4 (APOE4)

SUBMITTER: Eyamu J 

PROVIDER: S-EPMC12823931 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature