Risk factors for periprosthetic joint infection following primary total knee arthroplasty: a systematic review and meta-analysis.

ABSTRACT:

Objective

Periprosthetic joint infection (PJI) represents a severe and devastating complication following primary total knee arthroplasty (TKA), leading to higher morbidity and implant failure. However, existing evidence regarding its risk factors remains inconsistent.

Method

PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Chinese Journal Database, and the Chinese Biomedical Literature Service System (SinoMed) were searched for primary studies from the database inception to August 2025. Data were managed with EndNote X9 software, meta-analyses were performed using Review Manager 5.4, infection risk was analyzed using STATA 18, and the comprehensive incidence rate of PJI was analyzed using R 4.5.1.

Results

A total

SUBMITTER: Li J 

PROVIDER: S-EPMC12823960 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature