Preoperative serum creatinine changes and acute kidney injury in patients underwent cardiac surgery.

ABSTRACT:

Introduction

Preoperative serum creatinine fluctuations are common in open-heart surgery, and their association with postoperative acute kidney injury (AKI) and the combined impact on patient outcomes warrant further investigation.

Methods

This retrospective cohort study assessed patients undergoing open-heart surgery. Preoperative serum creatinine changes (ΔScr) were calculated as the difference between the serum creatinine value within 48 h before surgery and baseline. Patients were categorized into three groups based on ΔScr: negative (< 0 mg/dl), normal (0-0.3 mg/dl), and elevated (≥0.3 mg/dl). Multivariable logistic regression and restricted cubic spline models were used to analyze the clinical outcomes.

Results

Of the 560 patients included, 40.2% developed AKI.

SUBMITTER: Jiang B 

PROVIDER: S-EPMC12824009 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature