Glycine attenuates sepsis-induced white matter injury by modulating gut microbiota.

ABSTRACT: Sepsis poses a significant threat to preterm infants and is a leading cause of white matter injury (WMI); however, effective therapeutic strategies remain limited. Recent studies suggest that gut microbiota dysbiosis contributes to sepsis-induced systemic inflammation and neurological damage. After treating mice with LPS-induced sepsis with glycine, we evaluated pathological changes in the brain and ileum by HE staining and analyzed gut microbiota composition by 16S rRNA gene sequencing. Inflammatory cytokine levels in brain and ileal tissues were quantified by ELISA. Transcriptomic profiling was performed to identify differentially expressed genes and enriched pathways in the brains of septic mice with WMI. Additionally, protein expression levels of occludin, Iba-1, BMP, and C5aR1 were as

SUBMITTER: Liu J 

PROVIDER: S-EPMC12824023 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature