An Ethical Analysis of Public Attitudes towards Controlled Human Infection Studies in Singapore: Acceptability and Payment.

ABSTRACT: Singapore is conducting its first controlled human infection (CHI) study, and is administering SARS-CoV-2 as the challenge agent. Ahead of this study, we conducted a survey to assess public perceptions in Singapore of CHI studies in general and with SARS-CoV-2, and the ethical issues they raise, including those around payments to research participants. Overall, there was large support for challenge studies in Singapore, suggesting they could obtain a social license. However, a minority strongly disagreed, and most respondents reported limited pre-survey knowledge about CHI studies. Importantly, Singaporeans support a higher incentive model of payment than is usually employed in challenge study research. They support either a Market Model or a Payment for Risk Model. There was most support

SUBMITTER: Young B 

PROVIDER: S-EPMC12824035 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature