Voxel-based dosimetry for predicting treatment response to transarterial radioembolization in hepatocellular carcinoma: significance of intratumoral dose distribution.

ABSTRACT:

Purpose

We applied a voxel-based personalized dosimetry method using multiple voxel S-values (VSVs) to assess the intratumoral dose distribution in hepatocellular carcinoma (HCC) patients treated with trans-arterial radioembolization (TARE) using glass microspheres. This study aimed to evaluate the predictive value of dose metrics for treatment response and local progression-free survival (L-PFS).

Methods

Ninety patients with HCC who underwent TARE between November 2015 and December 2019 were retrospectively analyzed. Post-treatment ⁹⁰Y-microsphere PET/CT images were used to generate voxel-wise absorbed dose maps via convolution with CT-derived multiple VSV kernels. Tumor volumes were manually delineated on contrast-enhanced CT co-registered with dose map. Dose-vo

SUBMITTER: Suh M 

PROVIDER: S-EPMC12824089 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature