Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder.

ABSTRACT: Bipolar disorder (BD) is a severe mental disorder, characterized by episodes of mania and depression. The longitudinal neurobiological impact of BD episodes on brain structure remains largely unknown. In 124 age-sex-matched participants (62 BD patients; 62 healthy controls; HCs), aged 20-62 years, we investigated the longitudinal relationship between BD episodes and whole-brain gray matter volume (GMV) changes (3 Tesla MRI) during a two-year interval, using voxel-based morphometry in SPM12/CAT12. We compared GMV trajectories between BD patients with at least one depressive or manic episode during the two-year interval, BD patients without an episode, and HCs. We explored associations between GMV changes and clinical variables, like the number and duration of depressive or manic episodes bo

SUBMITTER: Thomas-Odenthal F 

PROVIDER: S-EPMC12824149 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature