The genetics of cannabis lifetime use.

ABSTRACT: Cannabis is one of the most commonly used drugs in the world, and use is trending alarmingly higher. We aimed to examine the genetic basis of cannabis lifetime use (CanLU) and its genetic relationships with a variety of psychiatric- and physical health-related phenotypes. We conducted a multi-ancestral genome-wide association study (GWAS) of CanLU using data from All of Us in five genetic populations. We meta-analyzed the results of EUR participants with previously published CanLU data (total effective sample size: 258,823), and conducted a set of post-GWAS analyses, including genetic correlation analysis using LDSC, local genetic correlation analysis with LAVA, Mendelian randomization (MR) to assess causality, and phenomewide association analysis. We found 11 independent variants signific

SUBMITTER: Bright U 

PROVIDER: S-EPMC12824155 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature