A metabolism-chromatin axis promotes differential ribosomal RNA transcription in the human malaria parasite.

ABSTRACT: The transmission of the most virulent human malaria parasite, Plasmodium falciparum, relies on its survival in the contrasting environments of the human host and mosquito vector. One of the most fascinating adaptations to this lifestyle is the specific silencing of individual rDNA genes in the human host that are de-repressed following host-to-vector transmission. In this study, we define the epigenetic signatures of rRNA transcription and find that rDNA silencing relies on aerobic glycolysis, the sole energy-generating pathway in the human host. We show that disruption of NAD⁺ regeneration during lactate fermentation promotes rDNA de-repression and identify the sirtuin histone deacetylase Sir2a as the mediator between fluctuating NAD⁺ levels and a functional transcri

SUBMITTER: Couble JE 

PROVIDER: S-EPMC12824157 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature