Plasma-activated solutions reverse chronic deltamethrin exposure induced intestinal injury via rebalancing redox homeostasis and counteracting cellular senescence.

ABSTRACT: Deltamethrin (DLM), a widely used pesticide, poses chronic exposure risks. Previous studies have shown its role in inducing intestinal mucosal barrier impairment. Meanwhile, plasma-activated solutions (PAS) ameliorate Dextran Sulfate Sodium (DSS)-induced colitis, primarily through the regulation of redox homeostasis. Building upon these findings, to further investigate the therapeutic potential of PAS against DLM-induced injury, we establish a chronic DLM exposure model in female BALB/c mice with concurrent free access to PAS. Intestinal tissues and serum are collected for H&E staining and measurement of serum inflammatory factors to assess inflammatory response. Immunofluorescence staining are used to detect intestinal injury and senescence. Reactive Oxygen Species (ROS) staining and glut

SUBMITTER: Deng X 

PROVIDER: S-EPMC12824175 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature