Circadian disruption aggravates non-alcoholic fatty liver disease by activating RIPK1-RIPK3-MLKL axis in mice.

ABSTRACT: Circadian disruption represents a significant risk factor for non-alcoholic fatty liver disease (NAFLD); however, the underlying regulatory mechanisms remain poorly understood. This study aims to investigate the impact of circadian disruption on NAFLD development in mice and to elucidate the associated molecular pathways. First, a NAFLD mouse model was established by feeding mice a high-fat diet over a period of 12 weeks, during which an intervention to disrupt the circadian rhythm was also implemented. The experimental groups included: the control group, the NAFLD model group, the circadian disruption group (CCD), and the NAFLD combined with circadian disruption group (NAFLD + CCD). Lipid accumulation and liver function were assessed using biochemical assay kits from each group. Serum lev

SUBMITTER: Li X 

PROVIDER: S-EPMC12824229 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature