Anti-cancer activity of propolis extracts from stingless bees of Brunei Darussalam.

ABSTRACT: Propolis from stingless bees is a natural resinous substance with diverse therapeutic properties, including anti-cancer activity. Despite increasing global interest, little is known about the bioactive potential of propolis from Southeast Asian stingless bees, particularly those native to Brunei Darussalam. Therefore, we investigated propolis extracts from five stingless bee species in Brunei and elucidated the underlying molecular mechanisms using transcriptomic and metabolomic profiling. Propolis extracts from Heterotrigona itama, Tetragonula melanoleuca, Tetrigona binghami, Geniotrigona thoracica, and Lepidotrigona canifrons were tested against lymphoma (U2932, HT, OCI-LY3), lung (H1975) and bladder (EJ) cancer cell lines. RNAseq and pathway enrichment analysis were performed to investi

SUBMITTER: Lim BY 

PROVIDER: S-EPMC12824237 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature