Wnt/FGF20 signaling axis promotes migration of proximal blastema cell during tail regeneration of Gekko japonicus.

ABSTRACT: The Wnt/FGF20 axis establishes an organizing center that is largely non-proliferative in the distal blastema during epimorphic regeneration across multiple model systems. However, the underlying mechanisms remain poorly characterized. In this study, we investigate the role of the Wnt/FGF20 axis during tail regeneration in Gekko japonicus. We also developed an in vitro system to evaluate the effects of Wnt agonists, FGF20, and FGFR4 on cultured blastema cells. Our results demonstrate that Wnt signaling is activated in distal blastema cells and contributes to a lower proportion of proliferative cells beneath the epidermal basal layer in the regenerating tail of Gekko japonicus. This Wnt-mediated suppression of proliferation is associated with reduced FGFR4 expression, as confirmed both in vi

SUBMITTER: Xu M 

PROVIDER: S-EPMC12824270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature