A dual-functional cobalt ferrite nanocomplex for targeted cisplatin prodrug delivery and MALAT1 gene silencing in gastric cancer cells.

ABSTRACT: Cisplatin (CDDP) is a common drug for gastric cancer (GC) treatment. The aberrant expression of MALAT-1, a long noncoding RNA, plays a critical role in CDDP resistance. Thus, silencing MALAT-1 using short hairpin RNAs (shRNA) can be an effective way to overcome CDDP resistance. The present study aims to use magnetic cobalt ferrite nanoparticles (CoFe₂O₄), functionalized with polyethyleneimine and chitosan, as targeted carriers for delivering Pt(IV)-COOH prodrug and shRNA-expressing cassettes to AGS cells. The shRNA-expressing cassettes were synthesized by PCR. Functionalized CoFe₂O₄ nanoparticles were synthesized, and their morphology, structural, and magnetic properties were evaluated using FESEM, EDAX, HRTEM, XRD, FT-IR, VSM and Zeta potential analyzer. The delivery

SUBMITTER: Doryani F 

PROVIDER: S-EPMC12824278 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature