Bone Marrow Mesenchymal Stromal Cells and Their Derived Extracellular Vesicles Protect Pancreatic Beta-TC-6 Cells From Hypoxia-Induced Injury via miR-539-3p-Mediated Downregulation of CD36 Expression.

ABSTRACT: Bone marrow mesenchymal stromal cells (BMSCs) have been shown to enhance the function of pancreatic beta-cells under hypoxic conditions. However, the precise mechanisms underlying this protective effect remain elusive. In this study, we established a hypoxic beta-cell model using murine pancreatic beta-TC-6 cells to investigate the protective effect and mechanism of BMSCs and their secreted extracellular vesicles (BMSC-EVs) on hypoxic β cells. Our findings reveal that coculture with BMSCs or BMSC-EVs significantly enhances the viability and survival of hypoxic beta-TC-6 cells. Molecularly, hypoxic conditions trigger an upregulation of CD36 in beta-TC-6 cells, a response that is counteracted by BMSCs or BMSC-EVs. Through a screening process for microRNAs (miRNAs) capable of degrading CD36 m

SUBMITTER: Lin N 

PROVIDER: S-EPMC12824418 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature