Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons.

ABSTRACT: Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle-related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC-MS/MS assay while accounting for key SLCO1B1 variants known to affect statin exposure. We further compared our results with published data across multiple ethnic populations via meta-analysis and conducted an exploratory pharmacogenetic analysis of SVA disposition-related genes to identify potential candidate variants contributing to PK differences observed between Thai and Caucasian populations. The pharmacokinetic results showed that aging significantly increased SV C_max but did

SUBMITTER: Srimatimanon T 

PROVIDER: S-EPMC12824591 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature