Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.

ABSTRACT:

Background

The spleen dose-volume threshold for lymphopenia in abdominal radiotherapy has not yet reached a consensus. Our previous research indicated a correlation between these factors, but the threshold has not been determined. Therefore, we investigated the dynamic changes in lymphocytes during radiotherapy (RT), identified the spleen dose threshold, and examined how these factors affect patient prognosis.

Methods

The absolute lymphocyte counts (ALC) of gastric cancer patients were collected before, during, and after RT. Lymphocyte recovery status was assessed using the lymphocyte recovery index (LRI). LRI cut off was considered as insufficient recovery. Splenic dosimetric parameters were collected, and their impact on predicting grade 4 (G4) lymphopenia was evaluated us

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12824635 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature