Tumor Microenvironment Characterization Identifies <i>KIF15</i> as an Immunosuppressive Driver in Breast Cancer.

ABSTRACT: The various cellular composition of the tumor microenvironment (TME) comprises the fundamental units of tumor tissue. The types of stromal cells in the TME are genetically stable, with reduced risk of tumor recurrence and drug resistance. More and more evidence shows their clinicopathological significance and therapeutic effect in predicting prognosis. Therefore, we performed an integrated analysis of the breast cancer TME, correlating it with genomic landscapes and clinical profiles. In this work, we first conducted unsupervised hierarchical clustering on 830 tumors in the breast cancer cohort. Then, we defined three TME phenotypes and applied principal component analysis to construct a TMEscore for quantifying TME. Analysis revealed that patients stratified into the high TMEscore cohort

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12824639 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature