Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone.

ABSTRACT:

Abstract

In inflammation, circulating neutrophils indirectly damage the skeleton by inducing formation of bone-resorbing osteoclasts. However, neutrophil progenitors in marrow have no known physiological function. A bone-protective role for the neutrophil lineage was recently suggested when a profound defect in bone structure was observed in mice with neutropenia due to granulocyte colony-stimulating factor deletion coupled with STAT3 hyperactivation in bone cells. Here, we tested the existence of this protective effect by manipulating neutrophil progenitors in bone marrow using anti-Ly6G (αLy6G) treatment. Two protocols revealed an inverse relationship between marrow neutrophil progenitors and osteoclasts. Two weeks of αLy6G treatment increased marrow immature neutrophils by 25%,

SUBMITTER: Isojima T 

PROVIDER: S-EPMC12824650 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature